TY - JOUR
T1 - Effect of a polymorphonuclear elastase inhibitor (Sivelestat sodium) on acute lung injury after cardiopulmonary bypass
T2 - Findings of a double-blind randomized study
AU - Ryugo, Masahiro
AU - Sawa, Yoshiki
AU - Takano, Hiroshi
AU - Matsumiya, Goro
AU - Iwai, Shigemitsu
AU - Ono, Masamichi
AU - Hata, Hiroki
AU - Yamauchi, Takashi
AU - Nishimura, Masaji
AU - Fujino, Yuji
AU - Matsuda, Hikaru
PY - 2006/4
Y1 - 2006/4
N2 - Purpose. We evaluated the effect of sivelestat sodium (SiV), a novel synthesized polymorphonuclear (PMN) elastase inhibitor, on acute lung injury (ALI) caused by cardiopulmonary bypass (CPB). Methods. Fourteen patients who underwent cardiopulmonary surgery using CPB, followed by the development of both systemic inflammatory response syndrome (SIRS) and ALI, were treated with either 0.2 mg/kg per hour SiV (SiV group, n = 7) or saline (control group, n = 7) for 4 days from the time of arrival in the intensive care unit. Results. The SiV group had a significantly lower ratio of serum PMN elastase and interleukin (IL)-8, a significantly lower ratio of the respiratory index, and a significantly higher ratio of PaO2/FiO2 after 24 h of treatment than the control group. Conclusion. Sivelestat sodium suppressed the production of PMN elastase and IL-8, resulting in improved respiratory function in patients with ALI caused by CPB.
AB - Purpose. We evaluated the effect of sivelestat sodium (SiV), a novel synthesized polymorphonuclear (PMN) elastase inhibitor, on acute lung injury (ALI) caused by cardiopulmonary bypass (CPB). Methods. Fourteen patients who underwent cardiopulmonary surgery using CPB, followed by the development of both systemic inflammatory response syndrome (SIRS) and ALI, were treated with either 0.2 mg/kg per hour SiV (SiV group, n = 7) or saline (control group, n = 7) for 4 days from the time of arrival in the intensive care unit. Results. The SiV group had a significantly lower ratio of serum PMN elastase and interleukin (IL)-8, a significantly lower ratio of the respiratory index, and a significantly higher ratio of PaO2/FiO2 after 24 h of treatment than the control group. Conclusion. Sivelestat sodium suppressed the production of PMN elastase and IL-8, resulting in improved respiratory function in patients with ALI caused by CPB.
KW - Acute lung injury
KW - Cardiopulmonary bypass
KW - Polymorphonuclear elastase
KW - Postperfusion syndrome
KW - Sivelestat sodium
KW - Systemic inflammatory response syndrome
UR - http://www.scopus.com/inward/record.url?scp=33645289699&partnerID=8YFLogxK
U2 - 10.1007/s00595-005-3160-y
DO - 10.1007/s00595-005-3160-y
M3 - Article
C2 - 16554988
AN - SCOPUS:33645289699
SN - 0941-1291
VL - 36
SP - 321
EP - 326
JO - Surgery Today
JF - Surgery Today
IS - 4
ER -