TY - JOUR
T1 - Early [18F]FET-PET in gliomas after surgical resection
T2 - Comparison with MRI and histopathology
AU - Kläsner, Benjamin
AU - Buchmann, Niels
AU - Gempt, Jens
AU - Ringel, Florian
AU - Lapa, Constantin
AU - Joachim Krause, Bernd
N1 - Publisher Copyright:
© 2015 Kläsner et al.
PY - 2015/10/26
Y1 - 2015/10/26
N2 - Background: The precise definition of the post-operative resection status in high-grade gliomas (HGG) is crucial for further management. We aimed to assess the feasibility of assessment of the resection status with early post-operative positron emission tomography (PET) using [18F] O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). Methods: 25 patients with the suspicion of primary HGG were enrolled. All patients underwent preoperative [18F]FET-PET and magnetic resonance imaging (MRI). Intra-operatively, resection status was assessed using 5-aminolevulinic acid (5-ALA). Imaging was repeated within 72h after neurosurgery. Post-operative [18F]FET-PET was compared with MRI, intra-operative assessment and clinical follow-up. Results: [18F]FET-PET, MRI and intra-operative assessment consistently revealed complete resection in 12/25 (48%) patients and incomplete resection in 6/25 cases (24%). In 7 patients, PET revealed discordant findings. One patient was re-resected. 3/7 experienced tumor recurrence, 3/7 died shortly after brain surgery. Conclusion Early assessment of the resection status in HGG with [18F]FET-PET seems to be feasible.
AB - Background: The precise definition of the post-operative resection status in high-grade gliomas (HGG) is crucial for further management. We aimed to assess the feasibility of assessment of the resection status with early post-operative positron emission tomography (PET) using [18F] O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). Methods: 25 patients with the suspicion of primary HGG were enrolled. All patients underwent preoperative [18F]FET-PET and magnetic resonance imaging (MRI). Intra-operatively, resection status was assessed using 5-aminolevulinic acid (5-ALA). Imaging was repeated within 72h after neurosurgery. Post-operative [18F]FET-PET was compared with MRI, intra-operative assessment and clinical follow-up. Results: [18F]FET-PET, MRI and intra-operative assessment consistently revealed complete resection in 12/25 (48%) patients and incomplete resection in 6/25 cases (24%). In 7 patients, PET revealed discordant findings. One patient was re-resected. 3/7 experienced tumor recurrence, 3/7 died shortly after brain surgery. Conclusion Early assessment of the resection status in HGG with [18F]FET-PET seems to be feasible.
UR - http://www.scopus.com/inward/record.url?scp=84949894947&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0141153
DO - 10.1371/journal.pone.0141153
M3 - Article
C2 - 26502297
AN - SCOPUS:84949894947
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 10
M1 - e0141153
ER -