Early determinants of type 1 diabetes: Experience from the BABYDIAB and BABYDIET studies

Sandra Hummel, Anette G. Ziegler

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Type 1 diabetes is an immune-mediated disorder that results from progressive destruction of the islet β cells. A genetic susceptibility for the development of islet autoimmunity and type 1 diabetes is well documented, and an environmental influence is assumed. Prospective studies from birth have shown that islet autoimmunity occurs very early in life, which implies that fetal or postnatal environmental factors may program the development of islet autoimmunity. In this overview, results from the BABYDIAB study, a prospective study from birth on the natural history of type 1 diabetes, and the BABYDIET study, a dietary intervention study, are discussed with a focus on the role of a diabetes environment in utero and the role of early gluten exposure on islet autoimmunity risk in children.

Original languageEnglish
Pages (from-to)1821S-1823S
JournalAmerican Journal of Clinical Nutrition
Volume94
Issue number6
DOIs
StatePublished - 1 Dec 2011
Externally publishedYes

Fingerprint

Dive into the research topics of 'Early determinants of type 1 diabetes: Experience from the BABYDIAB and BABYDIET studies'. Together they form a unique fingerprint.

Cite this