EAACI/GA2LEN guideline: Aspirin provocation tests for diagnosis of aspirin hypersensitivity

E. Nizankowska-Mogilnicka, G. Bochenek, L. Mastalerz, M. Świerczyńska, C. Picado, G. Scadding, M. L. Kowalski, M. Setkowicz, J. Ring, K. Brockow, C. Bachert, S. Wöhrl, B. Dahlén, A. Szczeklik

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Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis (AIA/R) and aspirin-induced urticaria/angioedema (AIU). The decisive diagnosis is based on provocation tests with aspirin, as the in vitro test does not hold diagnostic value as yet. Detailed protocols of oral, bronchial and nasal aspirin provocation tests are presented. Indications, contraindications for the tests, the rules of drug withdrawal and equipment are reviewed. Patient supervision and interpretations of the tests are proposed.

Original languageEnglish
Pages (from-to)1111-1118
Number of pages8
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number10
StatePublished - Oct 2007


  • Aspirin
  • Aspirin challenge
  • Aspirin-induced asthma/rhinitis
  • Aspirin-induced urticaria
  • Hypersensitivity


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