(E)-α,β-unsaturated amides from tertiary amines, olefins and CO via Pd/Cu-catalyzed aerobic oxidative N-dealkylation

Renyi Shi, Hua Zhang, Lijun Lu, Pei Gan, Yuchen Sha, Heng Zhang, Qiang Liu, Matthias Beller, Aiwen Lei

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

A novel Pd/Cu-catalyzed chemoselective aerobic oxidative N-dealkylation/carbonylation reaction has been developed. Tertiary amines are utilized as a "reservoir" of "active" secondary amines in this transformation, which inhibits the formation of undesired by-products and the deactivation of the catalysts. This protocol allows for an efficient and straightforward construction of synthetically useful and bioactive (E)-α,β-unsaturated amide derivatives from easily available tertiary amines, olefins and CO.

Original languageEnglish
Pages (from-to)3247-3250
Number of pages4
JournalChemical Communications
Volume51
Issue number15
DOIs
StatePublished - 21 Feb 2015
Externally publishedYes

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