Dynamics of Competitive Evolution on a Smooth Landscape

Weiqun Peng, Ulrich Gerland, Terence Hwa, Herbert Levine

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We study competitive DNA sequence evolution directed by in vitro protein binding. The steady-state dynamics of this process is well described by a shape-preserving pulse which decelerates and eventually reaches equilibrium. We explain this dynamical behavior within a continuum mean-field framework. Analytical results obtained on the motion of the pulse agree with simulations. Furthermore, finite population correction to the mean-field results are found to be insignificant.

Original languageEnglish
Pages (from-to)4
Number of pages1
JournalPhysical Review Letters
Volume90
Issue number8
DOIs
StatePublished - 2003
Externally publishedYes

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