TY - JOUR
T1 - Dynamics of beta‐adrenoceptor blockade with cetamolol.
AU - Coelho, J.
AU - Schnelle, K.
AU - Joubert, L.
AU - Ventura, D.
AU - Mullane, J.
PY - 1985/4
Y1 - 1985/4
N2 - Cetamolol is a new beta‐adrenoceptor blocking agent shown in animals to have moderate beta 1‐adrenoceptor selectivity and partial agonist activity. In healthy normal volunteers, beta 1‐adrenoceptor blockade was measured as the reduction of exercise‐induced tachycardia, systolic blood pressure, and double product at 2, 8, and 24 h after a single oral dose of 10, 25, and 50 mg cetamolol. beta 1‐adrenoceptor blockade was significantly linearly related to log serum cetamolol level, was maximal at 2 h, and was still clinically significant at 24 h. A crossover study of single 0, 10, and 25 mg doses confirmed these findings. 1985 The British Pharmacological Society
AB - Cetamolol is a new beta‐adrenoceptor blocking agent shown in animals to have moderate beta 1‐adrenoceptor selectivity and partial agonist activity. In healthy normal volunteers, beta 1‐adrenoceptor blockade was measured as the reduction of exercise‐induced tachycardia, systolic blood pressure, and double product at 2, 8, and 24 h after a single oral dose of 10, 25, and 50 mg cetamolol. beta 1‐adrenoceptor blockade was significantly linearly related to log serum cetamolol level, was maximal at 2 h, and was still clinically significant at 24 h. A crossover study of single 0, 10, and 25 mg doses confirmed these findings. 1985 The British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0022245280&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2125.1985.tb02663.x
DO - 10.1111/j.1365-2125.1985.tb02663.x
M3 - Article
C2 - 2859872
AN - SCOPUS:0022245280
SN - 0306-5251
VL - 19
SP - 411
EP - 416
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 4
ER -