Dynamic Kinetic resolution of α-amino acid esters in the presence of aldehydes

Daniel A. Schichl, Stephan Enthaler, Wolfgang Holla, Thomas Riermeier, Udo Kragl, Matthias Beller

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A convenient procedure for the racemization of α-amino acid esters in the presence of catalytic amounts of salicylaldehydes is described. The combination of this racemization protocol with lipase-catalyzed ester hydrolysis allows successful dynamic kinetic resolution of various α-amino acid esters. The corresponding α-amino acids are obtained in high yield and optical purity.

Original languageEnglish
Pages (from-to)3506-3512
Number of pages7
JournalEuropean Journal of Organic Chemistry
Issue number20
DOIs
StatePublished - Jul 2008
Externally publishedYes

Keywords

  • Amino acids
  • Biocatalysis
  • Enzymes
  • Kinetic resolution
  • Racemization

Fingerprint

Dive into the research topics of 'Dynamic Kinetic resolution of α-amino acid esters in the presence of aldehydes'. Together they form a unique fingerprint.

Cite this