Dynamic electrical switching of DNA layers on a metal surface

Ulrich Rant, Kenji Arinaga, Shozo Fujita, Naoki Yokoyama, Gerhard Abstreiter, Marc Tornow

Research output: Contribution to journalArticlepeer-review

157 Scopus citations

Abstract

We report on the dynamic control over the orientation of short oligonucleotide strands which are tethered to gold surfaces in electrolyte solution. By applying alternating electrical bias potentials to the supporting electrodes we are able to induce a switching of the layer conformation between a "lying" and a "standing" state, simultaneously monitored in a contactless mode by fluorescence techniques. We demonstrate that our electrooptical experiments allow for an in-depth investigation of the intriguing molecular dynamics of DMA at surfaces and, moreover, how the dynamic response of these switchable biomolecular layers opens new prospects in label-free biosensing.

Original languageEnglish
Pages (from-to)2441-2445
Number of pages5
JournalNano Letters
Volume4
Issue number12
DOIs
StatePublished - Dec 2004

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