Abstract
A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.
Original language | English |
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Pages (from-to) | 12077-12080 |
Number of pages | 4 |
Journal | Angewandte Chemie International Edition in English |
Volume | 52 |
Issue number | 46 |
DOIs | |
State | Published - 11 Nov 2013 |
Externally published | Yes |
Keywords
- biological signaling
- cell adhesion
- dynamics
- host-guest chemistry
- supramolecular chemistry