TY - JOUR
T1 - Dynamic Autoregulation Testing Does Not Indicate Changes of Cerebral Blood Flow Before and After Resection of Small- and Medium-Sized Cerebral AVM
AU - Stüer, Carsten
AU - Ikeda, Toshiki
AU - Stoffel, Michael
AU - Schaller, Carlo
AU - Meyer, Bernhard
N1 - Funding Information:
Disclosure / Conflict of Interest This work was supported by the German Research Council (DFG grant ME 1082/1-1). There was no further financial support to this work.
PY - 2011/3
Y1 - 2011/3
N2 - This study tested the hypothesis that dynamic cerebral autoregulation (AR) remains intact before and after the excision of human arteriovenous malformations (AVM). In 12 patients (six female and six male; mean age, 34 years) harboring cerebral AVMs (AVM group), and 15 patients (nine female/six male; mean age, 49 years) with deepseated lesions (e. g., small frontobasal meningiomas) approached by transsylvian dissection (control group), we continuously assessed cerebral blood flow (CBF) using a thermo-diffusion technique, and mean arterial blood pressure (MABP). AR was estimated post-hoc using correlation-coefficient autoregulatory-index (Mx) analysis. Measurements were compared according to groups (AVM/control) and times (pre/post), referred to as conditions before and after AVM resection and transsylvian dissection, respectively. All values are given as mean ± SD. The correlation index Mx was without significant difference among the study groups, indicating unimpaired autoregulatory function. Intragroup comparisons related to AVM nidus size (small- (≤3 cm) and medium-sized (3-6 cm)) did not show significant influence on autoregulation. The study shows that in patients harboring small- and mediumsized AVMs, dynamic autoregulatory function as estimated by correlation-coefficient index analysis seems to be intact in the surrounding cerebrovascular bed perioperatively.
AB - This study tested the hypothesis that dynamic cerebral autoregulation (AR) remains intact before and after the excision of human arteriovenous malformations (AVM). In 12 patients (six female and six male; mean age, 34 years) harboring cerebral AVMs (AVM group), and 15 patients (nine female/six male; mean age, 49 years) with deepseated lesions (e. g., small frontobasal meningiomas) approached by transsylvian dissection (control group), we continuously assessed cerebral blood flow (CBF) using a thermo-diffusion technique, and mean arterial blood pressure (MABP). AR was estimated post-hoc using correlation-coefficient autoregulatory-index (Mx) analysis. Measurements were compared according to groups (AVM/control) and times (pre/post), referred to as conditions before and after AVM resection and transsylvian dissection, respectively. All values are given as mean ± SD. The correlation index Mx was without significant difference among the study groups, indicating unimpaired autoregulatory function. Intragroup comparisons related to AVM nidus size (small- (≤3 cm) and medium-sized (3-6 cm)) did not show significant influence on autoregulation. The study shows that in patients harboring small- and mediumsized AVMs, dynamic autoregulatory function as estimated by correlation-coefficient index analysis seems to be intact in the surrounding cerebrovascular bed perioperatively.
KW - AVM
KW - Brain hemodynamics
KW - Cerebral arteriovenous malformation
KW - Cerebral autoregulation
UR - http://www.scopus.com/inward/record.url?scp=79951516760&partnerID=8YFLogxK
U2 - 10.1007/s12975-010-0031-7
DO - 10.1007/s12975-010-0031-7
M3 - Article
AN - SCOPUS:79951516760
SN - 1868-4483
VL - 2
SP - 60
EP - 66
JO - Translational Stroke Research
JF - Translational Stroke Research
IS - 1
ER -