Dynamic adoption of anergy by antigen-exhausted CD4+ T cells

Anne Trefzer; Pallavi Kadam; Shu Hung Wang; Stefanie Pennavaria; Benedikt Lober; Batuhan Akçabozan; Jan Kranich; Thomas Brocker; Naoko Nakano; Martin Irmler; Johannes Beckers; Tobias Straub; Reinhard Obst

doi:10.1016/j.celrep.2021.108748

Dynamic adoption of anergy by antigen-exhausted CD4⁺ T cells

Anne Trefzer, Pallavi Kadam, Shu Hung Wang, Stefanie Pennavaria, Benedikt Lober, Batuhan Akçabozan, Jan Kranich, Thomas Brocker, Naoko Nakano, Martin Irmler, Johannes Beckers, Tobias Straub, Reinhard Obst

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Abstract

In a system with regulatable antigen presentation in vivo, Trefzer et al. find TCR signaling, gene transcription, and functionalities reversibly regulated by dose and time of chronically persisting antigen. Comparisons with naturally anergic and tumor-infiltrating T cells suggest that signatures of anergy and exhaustion by antigen largely overlap.

Original language	English
Article number	108748
Journal	Cell Reports
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2021.108748
State	Published - 9 Feb 2021

Keywords

CD4 T cells
T cell receptor
anergy
exhaustion
gene expression
microarray
tolerance
transcriptomics
tuning

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10.1016/j.celrep.2021.108748

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abstract = "In a system with regulatable antigen presentation in vivo, Trefzer et al. find TCR signaling, gene transcription, and functionalities reversibly regulated by dose and time of chronically persisting antigen. Comparisons with naturally anergic and tumor-infiltrating T cells suggest that signatures of anergy and exhaustion by antigen largely overlap.",

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AU - Trefzer, Anne

AU - Kadam, Pallavi

AU - Wang, Shu Hung

AU - Pennavaria, Stefanie

AU - Lober, Benedikt

AU - Akçabozan, Batuhan

AU - Kranich, Jan

AU - Brocker, Thomas

AU - Nakano, Naoko

AU - Irmler, Martin

AU - Beckers, Johannes

AU - Straub, Tobias

AU - Obst, Reinhard

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AB - In a system with regulatable antigen presentation in vivo, Trefzer et al. find TCR signaling, gene transcription, and functionalities reversibly regulated by dose and time of chronically persisting antigen. Comparisons with naturally anergic and tumor-infiltrating T cells suggest that signatures of anergy and exhaustion by antigen largely overlap.

KW - CD4 T cells

KW - T cell receptor

KW - anergy

KW - exhaustion

KW - gene expression

KW - microarray

KW - tolerance

KW - transcriptomics

KW - tuning

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ER -

Dynamic adoption of anergy by antigen-exhausted CD4⁺ T cells

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Keywords

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