Duodenum-preserving resection of the head of the pancreas: The future

Helmut Friess, Michael W. Müller, Markus W. Büchler

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14 Scopus citations


In a randomized unicenter clinical study duodenum-preserving pancreatic head resection and pylorus-preserving Whipple operation were prospectively compared in patients with chronic pancreatitis. Preoperatively, 10 days and 6 head resectionmonths postoperatively the patients were investigated with regard to glucose tolerance, pain relief, weight gain, hospital readmission, professional rehabilitation and postoperative complications. In the 6 months’ follow-up, patients who underwent the duodenum-preserving pancreatic head resection had less pain, greater weight gain, a better glucose tolerance and a higher insulin secretion capacity than patients with the pylorus-preserving Whipple resection. The postoperative mortality was zero and the postoperative morbidity was comparable in both groups (duodenum-preserving pancreatic head resection; 3/20 patients (15%), pylorus-preserving Whipple operation 4/20 patients (20%)). Duodenum-preserving pancreatic head resection provides a better postoperative outcome than the pylorus-preserving Whipple resection. Therefore, it should be considered as a new standard operation in patients with chronic pancreatitis and pancreatic head-related complications.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalDigestive Surgery
Issue number3-6
StatePublished - 1994
Externally publishedYes


  • Duodenum-preserving pancreatic head resection
  • Pancreatitis, chronic
  • Prospective study
  • Pylorus-preserving whipple procedure


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