Duocarmycin analogues without a DNA-binding indole unit associate with aldehyde dehydrogenase1A1 and not DNA: A reply

Lutz F. Tietze; Stephan A. Sieber

doi:10.1002/anie.201301923

Duocarmycin analogues without a DNA-binding indole unit associate with aldehyde dehydrogenase1A1 and not DNA: A reply

Lutz F. Tietze, Stephan A. Sieber

Chair of Organic Chemistry II

Georg August Universität Göttingen

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

An open question: Activity-based protein profiling using seco-CBI derivative 1, containing a DNA-binding indole unit, showed that besides binding to DNA, compound 1 also interacts with aldehyde dehydrogenase1. However, for CBI compounds without an indole unit, the origin of their cytotoxicity has not been identified, yet.

Original language	English
Pages (from-to)	5447-5449
Number of pages	3
Journal	Angewandte Chemie International Edition in English
Volume	52
Issue number	21
DOIs	https://doi.org/10.1002/anie.201301923
State	Published - 17 May 2013

Keywords

DNA damage
activity-based protein profiling
antitumor agents
biological activity
duocarmycin

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10.1002/anie.201301923

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KW - activity-based protein profiling

KW - antitumor agents

KW - biological activity

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Duocarmycin analogues without a DNA-binding indole unit associate with aldehyde dehydrogenase1A1 and not DNA: A reply

Abstract

Keywords

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