Abstract
Reacquiring the target: A proteomic profiling approach has been used to show that aldehyde dehydrogenase 1 may be an additional or alternative target of duocarmycin. Selective inhibition of this enzyme in lung cancer cells explains the antitumor activity of duocarmycin analogues (see scheme).
| Original language | English |
|---|---|
| Pages (from-to) | 2874-2877 |
| Number of pages | 4 |
| Journal | Angewandte Chemie International Edition in English |
| Volume | 51 |
| Issue number | 12 |
| DOIs | |
| State | Published - 19 Mar 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- antitumor agents
- cancer
- duocarmycin
- natural products
- proteomics
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