Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells

Tanja Wirth; Kianga Schmuck; Lutz F. Tietze; Stephan A. Sieber

doi:10.1002/anie.201106334

Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells

Tanja Wirth, Kianga Schmuck, Lutz F. Tietze, Stephan A. Sieber

Chair of Organic Chemistry II

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Reacquiring the target: A proteomic profiling approach has been used to show that aldehyde dehydrogenase 1 may be an additional or alternative target of duocarmycin. Selective inhibition of this enzyme in lung cancer cells explains the antitumor activity of duocarmycin analogues (see scheme).

Original language	English
Pages (from-to)	2874-2877
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	51
Issue number	12
DOIs	https://doi.org/10.1002/anie.201106334
State	Published - 19 Mar 2012

Keywords

antitumor agents
cancer
duocarmycin
natural products
proteomics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201106334

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title = "Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells",

abstract = "Reacquiring the target: A proteomic profiling approach has been used to show that aldehyde dehydrogenase 1 may be an additional or alternative target of duocarmycin. Selective inhibition of this enzyme in lung cancer cells explains the antitumor activity of duocarmycin analogues (see scheme).",

keywords = "antitumor agents, cancer, duocarmycin, natural products, proteomics",

author = "Tanja Wirth and Kianga Schmuck and Tietze, {Lutz F.} and Sieber, {Stephan A.}",

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AU - Wirth, Tanja

AU - Schmuck, Kianga

AU - Tietze, Lutz F.

AU - Sieber, Stephan A.

PY - 2012/3/19

Y1 - 2012/3/19

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AB - Reacquiring the target: A proteomic profiling approach has been used to show that aldehyde dehydrogenase 1 may be an additional or alternative target of duocarmycin. Selective inhibition of this enzyme in lung cancer cells explains the antitumor activity of duocarmycin analogues (see scheme).

KW - antitumor agents

KW - cancer

KW - duocarmycin

KW - natural products

KW - proteomics

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U2 - 10.1002/anie.201106334

DO - 10.1002/anie.201106334

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JF - Angewandte Chemie International Edition in English

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Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells

Abstract

Keywords

UN SDGs

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