Downbeat nystagmus caused by a paramedian ponto-medullary lesion

Judith Wagner, Nadine Lehnen, Stefan Glasauer, Nicole Rettinger, Ulrich Büttner, Thomas Brandt, Michael Strupp

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Downbeat nystagmus (DBN) is rarely caused by lesions in sites other than the cerebellar (para-)floccular lobe. We describe a case of DBN secondary to a hemorrhaged venous cavernoma at the pontomedullary junction. This case provides new insights into the neuro-anatomical substrate of DBN. We propose that DBN arises from lesions in a brainstem-cerebellar feedback loop, which comprises cells of the pontine paramedian tract (PMT).

Original languageEnglish
Pages (from-to)1572-1574
Number of pages3
JournalJournal of Neurology
Issue number9
StatePublished - Sep 2009
Externally publishedYes


  • Downbeat nystagmus
  • Flocculus
  • Paramedian tract


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