Dosimetric measurements of 68Ga-high affinity DOTATATE: Twins in spirit – part III

Translated title of the contribution: Dosimetric measurements of 68Ga-high affinity DOTATATE: Twins in spirit – part III

Holger Hartmann, R. Freudenberg, L. Oehme, K. Zöphel, M. Schottelius, H. J. Wester, G. Wunderlich, J. Kotzerke, C. Brogsitter

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose:68Ga-labelled compounds are increasingly used for somatostatin-receptor scintigraphy because of their favourable biokinetic properties, a higher tumour-to-background contrast and higher diagnostic accuracy compared to the gamma-emitting tracer111In-DTPA-octreotide. Recently, we have introduced the new tracer68Ga-DOTA-3-iodo-Tyr3-Thr8-octreotide (68Ga-HA-DOTA-TATE). The present study demonstrates the biodistribution and radiation dosimetry of this tracer in humans. Patients, methods: Seven men were enrolled in this analysis. Every patient underwent a 20 min dynamic PET scan after intravenous injection of about 114 ± 9 MBq of68Ga-HA-DOTATATE. This was followed by two whole-body scans at 30 min p. i. and 120 min p. i. Blood radioactivity concentration was determined non-invasively from a ROI drawn over the aorta. Urine was collected until the time of the last scan. Liver, spleen, kidneys and urinary bladder wall were included in the dosimetric estimation that was carried out with the software package OLINDA 1.0. Results: Physiological68Ga-HA-DOTATATE uptake was observed in the pituitary gland, thyroid, salivary glands, liver, spleen, kidneys, urinary bladder, adrenals and intestine. Organs with the highest absorbed dose were spleen (0.26 ± 0.11 mSv/MBq), kidneys (0.14 ± 0.03 mSv/MBq) and liver (0.12 ± 0.02 mSv/MBq).The estimated effective dose was 0.024 ± 0.001 mSv/MBq. Conclusion: Our study demonstrates biokinetics and radiation exposure of the68Ga-labelled tracer HA-DOTATATE to be comparable to other68Ga-labelled SSR analogues in clinical use.

Translated title of the contributionDosimetric measurements of 68Ga-high affinity DOTATATE: Twins in spirit – part III
Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalNuklearMedizin
Volume53
Issue number5
DOIs
StatePublished - 2014

Keywords

  • Ga-HA-DOTATATE
  • PET
  • Radiation dosimetry
  • Somatostatin receptor imaging

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