DosePatch: physics-inspired cropping layout for patch-based Monte Carlo simulations to provide fast and accurate internal dosimetry

Francesca De Benetti, Julia Brosch-Lenz, Jorge Mario Guerra González, Carlos Uribe, Matthias Eiber, Nassir Navab, Thomas Wendler

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Dosimetry-based personalized therapy was shown to have clinical benefits e.g. in liver selective internal radiation therapy (SIRT). Yet, there is no consensus about its introduction into clinical practice, mainly as Monte Carlo simulations (gold standard for dosimetry) involve massive computation time. We addressed the problem of computation time and tested a patch-based approach for Monte Carlo simulations for internal dosimetry to improve parallelization. We introduce a physics-inspired cropping layout for patch-based MC dosimetry, and compare it to cropping layouts of the literature as well as dosimetry using organ-S-values, and dose kernels, taking whole-body Monte Carlo simulations as ground truth. This was evaluated in five patients receiving Yttrium-90 liver SIRT. Results: The patch-based Monte Carlo approach yielded the closest results to the ground truth, making it a valid alternative to the conventional approach. Our physics-inspired cropping layout and mosaicking scheme yielded a voxel-wise error of < 2% compared to whole-body Monte Carlo in soft tissue, while requiring only ≈ 10% of the time. Conclusions: This work demonstrates the feasibility and accuracy of physics-inspired cropping layouts for patch-based Monte Carlo simulations.

Original languageEnglish
Article number51
JournalEJNMMI Physics
Volume11
Issue number1
DOIs
StatePublished - Dec 2024

Keywords

  • Dose kernels
  • Dosimetry
  • Monte Carlo simulations
  • Organ-S-values
  • SIRT

Fingerprint

Dive into the research topics of 'DosePatch: physics-inspired cropping layout for patch-based Monte Carlo simulations to provide fast and accurate internal dosimetry'. Together they form a unique fingerprint.

Cite this