Dopamine and adult neurogenesis

Andreas Borta, Günter U. Höglinger

Research output: Contribution to journalReview articlepeer-review

180 Scopus citations


Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in Parkinson's disease?

Original languageEnglish
Pages (from-to)587-595
Number of pages9
JournalJournal of Neurochemistry
Issue number3
StatePublished - Feb 2007
Externally publishedYes


  • Adult neurogenesis
  • Dopamine
  • Parkinson's disease
  • Substantia nigra
  • Subventricular zone


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