Donor leukocyte transfusions for treatment of leukemic relapse after bone marrow transplantation

Hans Jochem Kolb

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Allogeneic bone marrow transplantation is an effective treatment of leukemia. Intensive chemo- and radiotherapy used for conditioning and T-cells of the graft contribute to the control ofleukemia. Animal experiments indicate that transfusion of lymphocytes from the marrow donor convert into complete chimerism without producing graft-versus-host disease, if delayed for two months or more. Transfusion of donor leukocytes (DLT) after marrow transplantation has induced lasting remissions in the majority of patients with chronic myelogenous leukemia (CML) in hematological or cytogenetic relapse, some patients with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), transformed phase CML and multiple myeloma (MMY). The mechanism of the graft-versus-leukemia reaction is discussed.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalVox Sanguinis
Volume74
Issue numberSUPPL. 2
DOIs
StatePublished - 1998
Externally publishedYes

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