DNA origami as a nanoscopic ruler for superresolution microscopy

Christian Steinhauer; Ralf Jungmann; Thomas L. Sobey; Friedrich C. Simmel; Philip Tinnefeld

doi:10.1002/anie.200903308

DNA origami as a nanoscopic ruler for superresolution microscopy

Christian Steinhauer, Ralf Jungmann, Thomas L. Sobey, Friedrich C. Simmel, Philip Tinnefeld

Chair of Physics of Synthetic Biological Systems

Research output: Contribution to journal › Article › peer-review

246 Scopus citations

Abstract

Resolving the distance: Rectangular DNA origami labeled with fluqrophres at specific positions has been used as a nanoscopic ruler. Super-resolution microscppy based on the subsequent localization of single molecules enables two fluoropheres at a distance of about 90 nm to be optically resolved. This combination of subdiffraction imaging and DNA nano technology opens up new avenues for studying name structure and then

Original language	English
Pages (from-to)	8870-8873
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	48
Issue number	47
DOIs	https://doi.org/10.1002/anie.200903308
State	Published - 9 Nov 2009

Keywords

Dna origami
Fluorescence microscopy molecular ruler
Nanoscoplc ruler
Super-resolution

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10.1002/anie.200903308

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KW - Super-resolution

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DNA origami as a nanoscopic ruler for superresolution microscopy

Abstract

Keywords

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