DNA-microarrays as tools for the identification of tumor specific gene expression profiles: Applications in tumor biology, diagnosis and therapy

M. S. Staege; U. E. Hattenhorst; I. Neumann; C. Hutter; S. Foja; S. Burdach

doi:10.1055/s-2003-39371

DNA-microarrays as tools for the identification of tumor specific gene expression profiles: Applications in tumor biology, diagnosis and therapy

M. S. Staege, U. E. Hattenhorst, I. Neumann, C. Hutter, S. Foja, S. Burdach

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

DNA-microarrays allow the analysis of almost the complete gene expression program of tumor samples and normal control samples in a single experiment. This allows the processing of a large number of samples in a reasonable short time. Tumor specific gene expression profiles can be used for molecular tumor classification and as a new diagnostic tool. In addition, the identification of tumor specific genes can help to understand the biology of tumor cells and identified genes can be used for the development of new therapeutic strategies. However, the huge amount of data generated by DNA-microarrays creates new challenges for data analysis. In addition, accuracy and reproducibility of the available techniques require complementary methods for verification of DNA-microarray data.

Original language	English
Pages (from-to)	135-138
Number of pages	4
Journal	Klinische Padiatrie
Volume	215
Issue number	3
DOIs	https://doi.org/10.1055/s-2003-39371
State	Published - 2003
Externally published	Yes

Keywords

DNA-Microarrays
Tumor (immuno)therapy
Tumor diagnosis

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abstract = "DNA-microarrays allow the analysis of almost the complete gene expression program of tumor samples and normal control samples in a single experiment. This allows the processing of a large number of samples in a reasonable short time. Tumor specific gene expression profiles can be used for molecular tumor classification and as a new diagnostic tool. In addition, the identification of tumor specific genes can help to understand the biology of tumor cells and identified genes can be used for the development of new therapeutic strategies. However, the huge amount of data generated by DNA-microarrays creates new challenges for data analysis. In addition, accuracy and reproducibility of the available techniques require complementary methods for verification of DNA-microarray data.",

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AU - Neumann, I.

AU - Hutter, C.

AU - Foja, S.

AU - Burdach, S.

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AB - DNA-microarrays allow the analysis of almost the complete gene expression program of tumor samples and normal control samples in a single experiment. This allows the processing of a large number of samples in a reasonable short time. Tumor specific gene expression profiles can be used for molecular tumor classification and as a new diagnostic tool. In addition, the identification of tumor specific genes can help to understand the biology of tumor cells and identified genes can be used for the development of new therapeutic strategies. However, the huge amount of data generated by DNA-microarrays creates new challenges for data analysis. In addition, accuracy and reproducibility of the available techniques require complementary methods for verification of DNA-microarray data.

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DNA-microarrays as tools for the identification of tumor specific gene expression profiles: Applications in tumor biology, diagnosis and therapy

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Keywords

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