Diversity oriented synthesis of benzoxazoles and benzothiazoles

Julia H. Spatz; Thorsten Bach; Michael Umkehrer; Julien Bardin; Günther Ross; Christoph Burdack; Jürgen Kolb

doi:10.1016/j.tetlet.2007.10.067

Diversity oriented synthesis of benzoxazoles and benzothiazoles

Julia H. Spatz
, Thorsten Bach
, Michael Umkehrer
, Julien Bardin
, Günther Ross
, Christoph Burdack
, Jürgen Kolb

Chair of Organic Chemistry 1

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A combinatorial synthetic route yielding benzoxazoles and benzothiazoles is described. The use of o-halophenylisocyanides in the Ugi reaction (U-4CR) followed by a copper-catalyzed cyclization affords the benzoxazole as well as the benzothiazole moiety in good yield and high diversity.

Original language	English
Pages (from-to)	9030-9034
Number of pages	5
Journal	Tetrahedron Letters
Volume	48
Issue number	51
DOIs	https://doi.org/10.1016/j.tetlet.2007.10.067
State	Published - 17 Dec 2007

Keywords

Benzothiazoles
Benzoxazoles
Copper-catalyzed cyclization
Cross-coupling
Multi-component reaction
Ugi-reaction

Access to Document

10.1016/j.tetlet.2007.10.067

Cite this

@article{c598f164afa94253a7d43e92508838be,

title = "Diversity oriented synthesis of benzoxazoles and benzothiazoles",

abstract = "A combinatorial synthetic route yielding benzoxazoles and benzothiazoles is described. The use of o-halophenylisocyanides in the Ugi reaction (U-4CR) followed by a copper-catalyzed cyclization affords the benzoxazole as well as the benzothiazole moiety in good yield and high diversity.",

keywords = "Benzothiazoles, Benzoxazoles, Copper-catalyzed cyclization, Cross-coupling, Multi-component reaction, Ugi-reaction",

author = "Spatz, \{Julia H.\} and Thorsten Bach and Michael Umkehrer and Julien Bardin and G{\"u}nther Ross and Christoph Burdack and J{\"u}rgen Kolb",

year = "2007",

month = dec,

day = "17",

doi = "10.1016/j.tetlet.2007.10.067",

language = "English",

volume = "48",

pages = "9030--9034",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "51",

}

TY - JOUR

T1 - Diversity oriented synthesis of benzoxazoles and benzothiazoles

AU - Spatz, Julia H.

AU - Bach, Thorsten

AU - Umkehrer, Michael

AU - Bardin, Julien

AU - Ross, Günther

AU - Burdack, Christoph

AU - Kolb, Jürgen

PY - 2007/12/17

Y1 - 2007/12/17

N2 - A combinatorial synthetic route yielding benzoxazoles and benzothiazoles is described. The use of o-halophenylisocyanides in the Ugi reaction (U-4CR) followed by a copper-catalyzed cyclization affords the benzoxazole as well as the benzothiazole moiety in good yield and high diversity.

AB - A combinatorial synthetic route yielding benzoxazoles and benzothiazoles is described. The use of o-halophenylisocyanides in the Ugi reaction (U-4CR) followed by a copper-catalyzed cyclization affords the benzoxazole as well as the benzothiazole moiety in good yield and high diversity.

KW - Benzothiazoles

KW - Benzoxazoles

KW - Copper-catalyzed cyclization

KW - Cross-coupling

KW - Multi-component reaction

KW - Ugi-reaction

UR - https://www.scopus.com/pages/publications/36248953954

U2 - 10.1016/j.tetlet.2007.10.067

DO - 10.1016/j.tetlet.2007.10.067

M3 - Article

AN - SCOPUS:36248953954

SN - 0040-4039

VL - 48

SP - 9030

EP - 9034

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Diversity oriented synthesis of benzoxazoles and benzothiazoles

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this