Diversity of oligodendrocytes and their progenitors

Leda Dimou; Mikael Simons

doi:10.1016/j.conb.2017.09.015

Diversity of oligodendrocytes and their progenitors

Leda Dimou
, Mikael Simons

Medicine and Health

University of Ulm
Munich Cluster for Systems Neurology (SyNergy)
German Center for Neurodegenerative Diseases (DZNE)
Max Planck Institute of Experimental Medicine

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

The established function of oligodendrocytes and their progenitors is to drive the cellular events of myelination, a highly diversified process necessary to match the needs of various neuronal subtypes and networks. The morphological and molecular heterogeneity of oligodendrocytes and their progenitors point to functions beyond establishing saltatory nerve conduction. Here, we review the diversity in the oligodendroglial lineage as well as the classical and new functions identified for oligodendrocytes and their progenitors. Because oligodendroglia remain highly responsive to environmental changes, they likely contribute to various neurological and psychiatric diseases.

Original language	English
Pages (from-to)	73-79
Number of pages	7
Journal	Current Opinion in Neurobiology
Volume	47
DOIs	https://doi.org/10.1016/j.conb.2017.09.015
State	Published - Dec 2017

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10.1016/j.conb.2017.09.015

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abstract = "The established function of oligodendrocytes and their progenitors is to drive the cellular events of myelination, a highly diversified process necessary to match the needs of various neuronal subtypes and networks. The morphological and molecular heterogeneity of oligodendrocytes and their progenitors point to functions beyond establishing saltatory nerve conduction. Here, we review the diversity in the oligodendroglial lineage as well as the classical and new functions identified for oligodendrocytes and their progenitors. Because oligodendroglia remain highly responsive to environmental changes, they likely contribute to various neurological and psychiatric diseases.",

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AB - The established function of oligodendrocytes and their progenitors is to drive the cellular events of myelination, a highly diversified process necessary to match the needs of various neuronal subtypes and networks. The morphological and molecular heterogeneity of oligodendrocytes and their progenitors point to functions beyond establishing saltatory nerve conduction. Here, we review the diversity in the oligodendroglial lineage as well as the classical and new functions identified for oligodendrocytes and their progenitors. Because oligodendroglia remain highly responsive to environmental changes, they likely contribute to various neurological and psychiatric diseases.

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DO - 10.1016/j.conb.2017.09.015

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Diversity of oligodendrocytes and their progenitors

Abstract

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