Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis

Santhosh Sundaresan, Ashok Chacko, Amit K. Dutta, Eesh Bhatia, Heiko Witt, René H.M. Te Morsche, Jan B.M.J. Jansen, Joost P.H. Drenth

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background/Aims: Tropical calcific pancreatitis (TCP) refers to a type of idiopathic pancreatitis prevalent in Asia. The trypsin inhibitor (SPINK1) N34S variant partially explains the genetic susceptibility to TCP. As anionic trypsinogen (PRSS2) G191R protects against chronic pancreatitis in Europeans, we investigated whether this variant protects from TCP in Indians. Methods: We enrolled 174 patients and 794 controls from two Indian tertiary care referral hospitals. We analyzed PRSS2 and SPINK1 variants by melting curve analysis, allele-specific discrimination assay, and sequencing. Results: G191R was detected in 1 TCP patient (0.6%) compared to 13 controls (1.6%; OR 0.27, 95% CI 0.03-2.1; p = 0.33). SPINK1 N34S was enriched in the TCP population 67/174 (38.5%) compared to controls 10/234 (4.3%; OR 14, 95% CI 6.9-28.3; p < 0.001). Conclusion: G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect. N34S SPINK1 represents the major genetic risk factor in TCP.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
Issue number1-2
StatePublished - Apr 2009
Externally publishedYes


  • CTRC sequencing
  • PRSS2
  • SPINK1
  • Tropical calcific pancreatitis


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