Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols

Xinjiang Cui, Yuehui Li, Christoph Topf, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

The "green" reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)3, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.

Original languageEnglish
Pages (from-to)10596-10599
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume54
Issue number36
DOIs
StatePublished - 1 Sep 2015
Externally publishedYes

Keywords

  • alcohols
  • carboxylic acids
  • homogeneous catalysis
  • hydrogenation
  • ruthenium

Fingerprint

Dive into the research topics of 'Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols'. Together they form a unique fingerprint.

Cite this