Direct catalytic N-alkylation of amines with carboxylic acids

Iván Sorribes, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


A straightforward process for the N-alkylation of amines has been developed applying readily available carboxylic acids and silanes as the hydride source. Complementary to known reductive aminations, effective C-N bond construction proceeds under mild conditions and allows obtaining a broad range of alkylated secondary and tertiary amines, including fluoroalkyl-substituted anilines as well as the bioactive compound Cinacalcet HCl.

Original languageEnglish
Pages (from-to)14314-14319
Number of pages6
JournalJournal of the American Chemical Society
Issue number40
StatePublished - 8 Oct 2014
Externally publishedYes


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