Differential regulation of myeloid-derived suppressor cells by Candida species

Anurag Singh, Felipe Lelis, Stefanie Braig, Iris Schäfer, Dominik Hartl, Nikolaus Rieber

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-albicans Candida species to induce and functionally modulate neutrophilic MDSCs, including C. glabrata, C. parapsilosis, C. dubliniensis, and C. krusei. Our data demonstrate that the extent of MDSC generation is largely dependent on the Candida species with MDSCs induced by C. krusei and C. glabrata showing a higher suppressive activity compared to MDSCs induced by C. albicans. In summary, these studies show that fungal MDSC induction is differentially regulated at the species level and differentially affects effector T-cell responses.

Original languageEnglish
Article number1624
JournalFrontiers in Microbiology
Volume7
Issue numberOCT
DOIs
StatePublished - 13 Oct 2016
Externally publishedYes

Keywords

  • Anti-fungal immunity
  • Candida
  • Dectin-1
  • Dectin-2
  • MDSCs
  • Myeloid-derived suppressor cells
  • T-cell suppression

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