Differential expression of TRAIL-R3 and TRAIL-R4 in human pancreatic cancer

Quan Liao, Helmut Friess, Jorg Kleeff, Markus W. Büchler

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Pancreatic cancer is one of the most aggressive cancers, in part due to its insensitivity to most treatment modalities. This resistance towards cytotoxic therapy is thought to be caused - at least in part - by a general resistance of pancreatic cancer cells towards apoptosis. TRAIL-R3 and TRAIL-R4, which belong to the TRAIL receptor family, can inhibit TRAIL-induced apoptosis. Patients and Methods: Seven normal pancreatic tissues and 7 pancreatic cancer tissues were analyzed using Northem blotting, Westem blotting and immunohistochemistry. Results: TRAIL-R3 mRNA and protein expression were generally weak in pancreatic cancers and normal pancreatic tissues. In contrast, TRAIL-R4 mRNA and protein were expressed at moderate to high levels in human pancreatic cancer tissues, but demonstrated weak to negative expression in the normal pancreas. Conclusion: TRAIL-R4 but not TRAIL-R3 levels were significantly different in pancreatic cancer in comparison to the nommal pancreas. These findings give new insight into the resistance mechanisms of pancreatic cancer towards TRAIL-mediated apoptosis.

Original languageEnglish
Pages (from-to)3153-3159
Number of pages7
JournalAnticancer Research
Volume21
Issue number5
StatePublished - 2001
Externally publishedYes

Keywords

  • Apoptosis
  • Pancreatic cancer
  • TRAIL-R3
  • TRAIL-R4

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