Differential diffuse optical tomography

Vasilis Ntziachristos, Britton Chance, A. G. Yodh

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


We formulate a perturbative solution for the heterogeneous diffusion equation which demonstrates how to use differential changes in diffuse light transmission to construct images of tissue absorption changes following contrast agent administration. The analysis exposes approximations leading to an intuitive and simplified inverse algorithm, shows explicitly why transmission geometries are less susceptible to error than the remission geometries, and why differential measurements are less susceptible to surface artifacts. These ideas about differential diffuse optical tomography are not only applicable to tumor detection and characterization using contrast agents, but also to functional activation studies with or without contrast agents and multi-wavelength measurements.

Original languageEnglish
Pages (from-to)230-242
Number of pages13
JournalOptics Express
Issue number10
StatePublished - Nov 1999
Externally publishedYes


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