Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)

H. Peter; J. G. Filser; L. v. Szentpály; H. J. Wiegand

doi:10.1007/BF00297122

Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)

H. Peter, J. G. Filser, L. v. Szentpály, H. J. Wiegand

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism. However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.

Original language	English
Pages (from-to)	282-283
Number of pages	2
Journal	Archives of Toxicology
Volume	58
Issue number	4
DOIs	https://doi.org/10.1007/BF00297122
State	Published - Apr 1986
Externally published	Yes

Keywords

Chlorodifluoromethane
Dichlorofluoromethane
Pharmacokinetics

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10.1007/BF00297122

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title = "Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)",

abstract = "Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism. However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.",

keywords = "Chlorodifluoromethane, Dichlorofluoromethane, Pharmacokinetics",

author = "H. Peter and Filser, {J. G.} and {v. Szentp{\'a}ly}, L. and Wiegand, {H. J.}",

year = "1986",

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doi = "10.1007/BF00297122",

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T1 - Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)

AU - Peter, H.

AU - Filser, J. G.

AU - v. Szentpály, L.

AU - Wiegand, H. J.

PY - 1986/4

Y1 - 1986/4

N2 - Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism. However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.

AB - Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism. However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.

KW - Chlorodifluoromethane

KW - Dichlorofluoromethane

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=0022522991&partnerID=8YFLogxK

U2 - 10.1007/BF00297122

DO - 10.1007/BF00297122

M3 - Letter

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EP - 283

JO - Archives of Toxicology

JF - Archives of Toxicology

IS - 4

ER -

Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)

Abstract

Keywords

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