Different outcomes of chronic hepatitis delta virus infection in woodchucks

U. Schlipköter; A. Ponzetto; K. Fuchs; R. Rasshofer; S. S. Choi; S. Roos; M. Rapicetta; M. Roggendorf

doi:10.1111/j.1600-0676.1990.tb00472.x

Different outcomes of chronic hepatitis delta virus infection in woodchucks

U. Schlipköter, A. Ponzetto, K. Fuchs, R. Rasshofer, S. S. Choi, S. Roos, M. Rapicetta, M. Roggendorf

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Abstract— Hepatitis delta virus (HDV) superinfection of woodchuck chronic carriers of woodchuck hepatitis virus (WHV) results in acute and chronic disease. The different courses of disease mimicked the outcome of human HDV superinfection, making woodchucks valuable models for clinical studies of HDV. Ten of 11 woodchuck chronic carriers of WHV superinfected with HDV developed acute HDV infection with markers of viral replication in the serum and liver. One animal (DW128) had no serological markers of acute HDV infection. Nine of 11 (82%) superinfected animals developed chronic HDV infection. An unusual course of chronic HDV infection occurred in one woodchuck (DW128): no serum markers of acute or chronic HDV infection appeared but HDV RNA was detected in the liver, indicating that chronic HDV infection can occur without serological markers.

Original language	English
Pages (from-to)	291-301
Number of pages	11
Journal	Liver
Volume	10
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0676.1990.tb00472.x
State	Published - Oct 1990
Externally published	Yes

Keywords

HDV infection
chronic hepatitis
woodchuck

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0676.1990.tb00472.x

Cite this

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title = "Different outcomes of chronic hepatitis delta virus infection in woodchucks",

abstract = "Abstract— Hepatitis delta virus (HDV) superinfection of woodchuck chronic carriers of woodchuck hepatitis virus (WHV) results in acute and chronic disease. The different courses of disease mimicked the outcome of human HDV superinfection, making woodchucks valuable models for clinical studies of HDV. Ten of 11 woodchuck chronic carriers of WHV superinfected with HDV developed acute HDV infection with markers of viral replication in the serum and liver. One animal (DW128) had no serological markers of acute HDV infection. Nine of 11 (82%) superinfected animals developed chronic HDV infection. An unusual course of chronic HDV infection occurred in one woodchuck (DW128): no serum markers of acute or chronic HDV infection appeared but HDV RNA was detected in the liver, indicating that chronic HDV infection can occur without serological markers.",

keywords = "HDV infection, chronic hepatitis, woodchuck",

author = "U. Schlipk{\"o}ter and A. Ponzetto and K. Fuchs and R. Rasshofer and Choi, {S. S.} and S. Roos and M. Rapicetta and M. Roggendorf",

year = "1990",

month = oct,

doi = "10.1111/j.1600-0676.1990.tb00472.x",

language = "English",

volume = "10",

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TY - JOUR

T1 - Different outcomes of chronic hepatitis delta virus infection in woodchucks

AU - Schlipköter, U.

AU - Ponzetto, A.

AU - Fuchs, K.

AU - Rasshofer, R.

AU - Choi, S. S.

AU - Roos, S.

AU - Rapicetta, M.

AU - Roggendorf, M.

PY - 1990/10

Y1 - 1990/10

N2 - Abstract— Hepatitis delta virus (HDV) superinfection of woodchuck chronic carriers of woodchuck hepatitis virus (WHV) results in acute and chronic disease. The different courses of disease mimicked the outcome of human HDV superinfection, making woodchucks valuable models for clinical studies of HDV. Ten of 11 woodchuck chronic carriers of WHV superinfected with HDV developed acute HDV infection with markers of viral replication in the serum and liver. One animal (DW128) had no serological markers of acute HDV infection. Nine of 11 (82%) superinfected animals developed chronic HDV infection. An unusual course of chronic HDV infection occurred in one woodchuck (DW128): no serum markers of acute or chronic HDV infection appeared but HDV RNA was detected in the liver, indicating that chronic HDV infection can occur without serological markers.

AB - Abstract— Hepatitis delta virus (HDV) superinfection of woodchuck chronic carriers of woodchuck hepatitis virus (WHV) results in acute and chronic disease. The different courses of disease mimicked the outcome of human HDV superinfection, making woodchucks valuable models for clinical studies of HDV. Ten of 11 woodchuck chronic carriers of WHV superinfected with HDV developed acute HDV infection with markers of viral replication in the serum and liver. One animal (DW128) had no serological markers of acute HDV infection. Nine of 11 (82%) superinfected animals developed chronic HDV infection. An unusual course of chronic HDV infection occurred in one woodchuck (DW128): no serum markers of acute or chronic HDV infection appeared but HDV RNA was detected in the liver, indicating that chronic HDV infection can occur without serological markers.

KW - HDV infection

KW - chronic hepatitis

KW - woodchuck

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U2 - 10.1111/j.1600-0676.1990.tb00472.x

DO - 10.1111/j.1600-0676.1990.tb00472.x

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AN - SCOPUS:0025095989

SN - 0106-9543

VL - 10

SP - 291

EP - 301

JO - Liver

JF - Liver

IS - 5

ER -

Different outcomes of chronic hepatitis delta virus infection in woodchucks

Abstract

Keywords

UN SDGs

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