Diesel soot particles catalyze the production of oxy-radicals

Georg Vogl; Erich F. Elstner

doi:10.1016/0378-4274(89)90082-9

Diesel soot particles catalyze the production of oxy-radicals

Georg Vogl, Erich F. Elstner

Life Sciences

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The formation of a strong oxidant similar to the OH radical is catalyzed by diesel soot particles in the presence of cysteine and hydrogen peroxide or in the presence of light. The oxidant(s) formed causes fragmentation of methylthioketobutyric acid measurable as ethylene release. Furthermore, the model carotenoid crocin is bleached and thiobarbituric-acid-reactive material (malondialdehyde) is produced from linolenic acid. All reactions are inhibited by scavengers (propyl gallate, α-tocopherol, diazobicyclooctane) and by catalase. The reactions observed suggest that the toxicity and mutagenicity of diesel soot particles is at least in part due to the formation of reactive oxygen species.

Original language	English
Pages (from-to)	17-23
Number of pages	7
Journal	Toxicology Letters
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(89)90082-9
State	Published - Apr 1989

Keywords

Air pollution
Diesel soot particles
Hydrogen peroxide
Reactive oxygen species

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10.1016/0378-4274(89)90082-9

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title = "Diesel soot particles catalyze the production of oxy-radicals",

abstract = "The formation of a strong oxidant similar to the OH radical is catalyzed by diesel soot particles in the presence of cysteine and hydrogen peroxide or in the presence of light. The oxidant(s) formed causes fragmentation of methylthioketobutyric acid measurable as ethylene release. Furthermore, the model carotenoid crocin is bleached and thiobarbituric-acid-reactive material (malondialdehyde) is produced from linolenic acid. All reactions are inhibited by scavengers (propyl gallate, α-tocopherol, diazobicyclooctane) and by catalase. The reactions observed suggest that the toxicity and mutagenicity of diesel soot particles is at least in part due to the formation of reactive oxygen species.",

keywords = "Air pollution, Diesel soot particles, Hydrogen peroxide, Reactive oxygen species",

author = "Georg Vogl and Elstner, {Erich F.}",

note = "Funding Information: This work was supported by Shell Int. Petroleum Mats., The Hague, Netherlands, and Bayerisches Staatsministerium fur Landesentwicklung Umweltfragen, Munich, F.R.G.",

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AU - Vogl, Georg

AU - Elstner, Erich F.

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N2 - The formation of a strong oxidant similar to the OH radical is catalyzed by diesel soot particles in the presence of cysteine and hydrogen peroxide or in the presence of light. The oxidant(s) formed causes fragmentation of methylthioketobutyric acid measurable as ethylene release. Furthermore, the model carotenoid crocin is bleached and thiobarbituric-acid-reactive material (malondialdehyde) is produced from linolenic acid. All reactions are inhibited by scavengers (propyl gallate, α-tocopherol, diazobicyclooctane) and by catalase. The reactions observed suggest that the toxicity and mutagenicity of diesel soot particles is at least in part due to the formation of reactive oxygen species.

AB - The formation of a strong oxidant similar to the OH radical is catalyzed by diesel soot particles in the presence of cysteine and hydrogen peroxide or in the presence of light. The oxidant(s) formed causes fragmentation of methylthioketobutyric acid measurable as ethylene release. Furthermore, the model carotenoid crocin is bleached and thiobarbituric-acid-reactive material (malondialdehyde) is produced from linolenic acid. All reactions are inhibited by scavengers (propyl gallate, α-tocopherol, diazobicyclooctane) and by catalase. The reactions observed suggest that the toxicity and mutagenicity of diesel soot particles is at least in part due to the formation of reactive oxygen species.

KW - Air pollution

KW - Diesel soot particles

KW - Hydrogen peroxide

KW - Reactive oxygen species

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Diesel soot particles catalyze the production of oxy-radicals

Abstract

Keywords

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