DIE WIRKUNG VON QUINAPRIL AUF DEN BLUTDRUCK BEI ESSENTIELLER HYPERTONIE IN RUHE UND BEI ISOMETRISCHER BELASTUNG

Translated title of the contribution: The effect of quinapril on blood pressure in essential hypertension at rest and during isometric stress

H. R. Schon, L. Hess, B. Schaffhauser, J. Eichhorn

Research output: Contribution to journalArticlepeer-review

Abstract

In a multicenter study the effects of a six weeks therapy of 10-20 mg Quinapril per day on blood pressure and heart rate at rest and during isometric handgrip exercise were studied in 255 patients with mild to moderate essential hypertension and compared to 68 healthy normal subjects. After six weeks blood pressure at rest decreased from 165.1 ± 14.7/100.2 ± 7.2 mm Hg to 145.6 ± 12.4/88.4 ± 7.4 mm Hg (p < 0.001). The major effect could be seen already on day 8. A dose increase on day 8 induced a further decline in blood pressure (p < 0.001). Heart rate at rest was reduced slightly (2 bpm, p < 0.001) and was unaffected by a further increase in dosage. At peak isometric exercise blood pressure fell from 183.3 ± 8.4/110.5 ± 12.0 mm Hg to 160.9 ± 15.6/98.3 ± 11.6 mm Hg (p < 0.001). The exercise induced increase of systolic blood pressure was lower after six weeks of therapy than on day 1 (p < 0.01), whereas the increases of diastolic blood pressure and heart rate were not significantly different to day 1. Compared to healthy normal subjects hypertensive patients after six weeks Quinapril treatment only demonstrated a slight increase in heart rate at peak exercise (p < 0.05), however, no change in the exercise induced elevation of systolic and diastolic blood pressure. These data show that the patients with mild to moderate hypertension Quinapril is particularly effective in lowering blood pressure at rest and exercise thereby preserving the physiologic hemodynamic response to exercise similar to healthy normal subjects.

Translated title of the contributionThe effect of quinapril on blood pressure in essential hypertension at rest and during isometric stress
Original languageGerman
Pages (from-to)1226-1235
Number of pages10
JournalArs Medici
Volume85
Issue number17
StatePublished - 1995

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