Abstract
Molecular approaches for genome analysis in livestock are reviewed by discussing the contribution of molecular genome analysis to the identification of the genetic variation underlying phenotypic variation (structural genome analysis) and to the definition of the trait-associated and environment-affected gene expression (functional genome analysis) as an important prerequisite to understand the formation of a phenotype. Results of the German genome analysis projects in cattle and pig are summarised and aspects and limitations of the utilisation of mapped 'quantitative trait loci' (QTL) in breeding programs and the final cloning of the corresponding causal genes are discussed. Prerequisites, currant status and further challenges of applications of functional genomics in identification of functional candidate genes, in functional mapping of genes to complex traits and in estimation of the effects of environmental factors are referred.
| Translated title of the contribution | Structural and functional genomics - New ways to understand the phenotype |
|---|---|
| Original language | German |
| Pages (from-to) | 1-16 |
| Number of pages | 16 |
| Journal | Zuchtungskunde |
| Volume | 78 |
| Issue number | 1 |
| State | Published - Jan 2006 |