Abstract
Receptors for regulatory gut/brain peptides are expressed on gastrointestinal tumors and tumor cell lines. This review summarizes data on those agonists and antagonists of peptides which effect the growth of human gastrointestinal tumors. Growth of pancreatic and colon carcinomas is retarded by gastrin and its agonists in vitro and in nude mice but not in men. A significant role of gastrin in human colorectal and stomach cancers has recently been discussed. Cholecystokinin and its agonists/antagonists did not stop the growth of pancreatic carcinomas in patients. In vitro growth of pancreatic and colon cancer cell lines could be stimulated via receptors for neurotensin. Vasoactive intestinal peptide (VIP) has ambivalent effects on the growth of gastrointestinal tumors. Peptide YY decreases the growth of human pancreatic and colon cancer cell lines. Somatostatin and its agonists are successfully used for therapy of neuroendocrine tumors. They also could be effective in therapy of colon and hepatocellular carcinomas.
| Translated title of the contribution | The role of gastrointestinal hormones for the growth of gastrointestinal malignancies |
|---|---|
| Original language | German |
| Pages (from-to) | 1-13 |
| Number of pages | 13 |
| Journal | Tumor Diagnostik und Therapie |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
