Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

Sebastian Brings; Thomas Fleming; Marc Freichel; Martina U. Muckenthaler; Stephan Herzig; Peter P. Nawroth

doi:10.3390/ijms18050984

Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

Sebastian Brings
, Thomas Fleming
, Marc Freichel
, Martina U. Muckenthaler
, Stephan Herzig
, Peter P. Nawroth

Universitätsklinikum Heidelberg
German Centre for Diabetes Research (DZD)
Helmholtz Zentrum München German Research Center for Environmental Health
Heidelberg University

Research output: Contribution to journal › Review article › peer-review

191 Scopus citations

Abstract

Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.

Original language	English
Article number	984
Journal	International Journal of Molecular Sciences
Volume	18
Issue number	5
DOIs	https://doi.org/10.3390/ijms18050984
State	Published - 5 May 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3-deoxyglucosone
Advanced glycation end-products
Aldose reductase
Diabetes
Glyoxal
Glyoxalase
Methylglyoxal

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10.3390/ijms18050984

Cite this

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title = "Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention",

abstract = "Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.",

keywords = "3-deoxyglucosone, Advanced glycation end-products, Aldose reductase, Diabetes, Glyoxal, Glyoxalase, Methylglyoxal",

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AU - Brings, Sebastian

AU - Fleming, Thomas

AU - Freichel, Marc

AU - Muckenthaler, Martina U.

AU - Herzig, Stephan

AU - Nawroth, Peter P.

PY - 2017/5/5

Y1 - 2017/5/5

N2 - Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.

AB - Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.

KW - 3-deoxyglucosone

KW - Advanced glycation end-products

KW - Aldose reductase

KW - Diabetes

KW - Glyoxal

KW - Glyoxalase

KW - Methylglyoxal

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DO - 10.3390/ijms18050984

M3 - Review article

C2 - 28475116

AN - SCOPUS:85019078365

SN - 1661-6596

VL - 18

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 5

M1 - 984

ER -

Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

Abstract

UN SDGs

Keywords

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