Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose: Aktueller Stand und Empfehlungen in Deutschland

Stefan Bittner; Sinah Engel; Christoph Lange; Martin S. Weber; Aiden Haghikia; Felix Luessi; Thomas Korn; Luisa Klotz; Antonios Bayas; Friedemann Paul; Christoph Heesen; Martin Stangel; Brigitte Wildemann; Florian Then Bergh; Björn Tackenberg; Corinna Trebst; Clemens Warnke; Ralf Linker; Martin Kerschensteiner; Uwe Zettl; Hayrettin Tumani; Wolfgang Brück; Sven G. Meuth; Tanja Kümpfel; Bernhard Hemmer; Heinz Wiendl; Ralf Gold; Frauke Zipp

doi:10.1007/s00115-019-0760-0

Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose: Aktueller Stand und Empfehlungen in Deutschland

Translated title of the contribution: Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis: Current status and recommendations in Germany

Stefan Bittner
, Sinah Engel
, Christoph Lange
, Martin S. Weber
, Aiden Haghikia
, Felix Luessi
, Thomas Korn
, Luisa Klotz
, Antonios Bayas
, Friedemann Paul
, Christoph Heesen
, Martin Stangel
, Brigitte Wildemann
, Florian Then Bergh
, Björn Tackenberg
, Corinna Trebst
, Clemens Warnke
, Ralf Linker
, Martin Kerschensteiner
, Uwe Zettl

Hayrettin Tumani, Wolfgang Brück, Sven G. Meuth, Tanja Kümpfel, Bernhard Hemmer, Heinz Wiendl, Ralf Gold, Frauke Zipp

University Medical Center
Forschungszentrum Borstel - Zentrum für Medizin und Biowissenschaften
Deutsches Zentrum für Infektionsforschung (DZIF)
University of Lübeck
Karolinska Institutet
University Medical Center
Huntington-Zentrum (NRW) Bochum im St. Josef Hospital
Munich Cluster for Systems Neurology (SyNergy)
Universitätsklinikum Münster
Universitätsklinikum Augsburg
Max Delbrück Center for Molecular Medicine
University Medical Center Hamburg-Eppendorf
Hannover Medical School
University Hospital Heidelberg
University Hospital Leipzig
Philipps-Universität Marburg
University Hospital of Cologne
Klinikum der Universität Regensburg und Medizinische Fakultät
University of Munich
Rostock University Medical Center
University Medical Center Ulm and Center of Excellence 'Metabolic Disorders'
Klinik für Neurologie Dietenbronn

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

After years of low incidence, a large increase of new tuberculosis (TB) cases has been reported in Germany since 2015. New immunotherapies for the treatment of multiple sclerosis (MS) are associated with a reduced immune competence and a potential increased risk for infections. Most neurologists lack specific experiences with TB infections. This article summarizes specific recommendations for the diagnostics and treatment of TB under MS immunotherapies with a focus on the situation in Germany. Due to low case numbers and little experience with the risk of TB under the new immunotherapies, the clinical competence network for MS (KKNMS) consensus recommendations have a low grade of evidence.

Translated title of the contribution	Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis: Current status and recommendations in Germany
Original language	German
Pages (from-to)	1245-1253
Number of pages	9
Journal	Nervenarzt
Volume	90
Issue number	12
DOIs	https://doi.org/10.1007/s00115-019-0760-0
State	Published - 1 Dec 2019

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10.1007/s00115-019-0760-0

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Bittner, S., Engel, S., Lange, C., Weber, M. S., Haghikia, A., Luessi, F., Korn, T., Klotz, L., Bayas, A., Paul, F., Heesen, C., Stangel, M., Wildemann, B., Bergh, F. T., Tackenberg, B., Trebst, C., Warnke, C., Linker, R., Kerschensteiner, M., ... Zipp, F. (2019). Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose: Aktueller Stand und Empfehlungen in Deutschland. Nervenarzt, 90(12), 1245-1253. https://doi.org/10.1007/s00115-019-0760-0

@article{e7d49762f37642628555c1b896b695d0,

title = "Diagnostik und Therapie von Tuberkulose unter Immuntherapien f{\"u}r Multiple Sklerose: Aktueller Stand und Empfehlungen in Deutschland",

abstract = "After years of low incidence, a large increase of new tuberculosis (TB) cases has been reported in Germany since 2015. New immunotherapies for the treatment of multiple sclerosis (MS) are associated with a reduced immune competence and a potential increased risk for infections. Most neurologists lack specific experiences with TB infections. This article summarizes specific recommendations for the diagnostics and treatment of TB under MS immunotherapies with a focus on the situation in Germany. Due to low case numbers and little experience with the risk of TB under the new immunotherapies, the clinical competence network for MS (KKNMS) consensus recommendations have a low grade of evidence.",

keywords = "Immune monitoring, Multiple sclerosis, Prevention, Treatment, Tuberculosis",

author = "Stefan Bittner and Sinah Engel and Christoph Lange and Weber, \{Martin S.\} and Aiden Haghikia and Felix Luessi and Thomas Korn and Luisa Klotz and Antonios Bayas and Friedemann Paul and Christoph Heesen and Martin Stangel and Brigitte Wildemann and Bergh, \{Florian Then\} and Bj{\"o}rn Tackenberg and Corinna Trebst and Clemens Warnke and Ralf Linker and Martin Kerschensteiner and Uwe Zettl and Hayrettin Tumani and Wolfgang Br{\"u}ck and Meuth, \{Sven G.\} and Tanja K{\"u}mpfel and Bernhard Hemmer and Heinz Wiendl and Ralf Gold and Frauke Zipp",

note = "Publisher Copyright: {\textcopyright} 2019, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.",

year = "2019",

month = dec,

day = "1",

doi = "10.1007/s00115-019-0760-0",

language = "Deutsch",

volume = "90",

pages = "1245--1253",

journal = "Nervenarzt",

issn = "0028-2804",

publisher = "Springer Medizin",

number = "12",

}

Bittner, S, Engel, S, Lange, C, Weber, MS, Haghikia, A, Luessi, F, Korn, T, Klotz, L, Bayas, A, Paul, F, Heesen, C, Stangel, M, Wildemann, B, Bergh, FT, Tackenberg, B, Trebst, C, Warnke, C, Linker, R, Kerschensteiner, M, Zettl, U, Tumani, H, Brück, W, Meuth, SG, Kümpfel, T, Hemmer, B, Wiendl, H, Gold, R & Zipp, F 2019, 'Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose: Aktueller Stand und Empfehlungen in Deutschland', Nervenarzt, vol. 90, no. 12, pp. 1245-1253. https://doi.org/10.1007/s00115-019-0760-0

TY - JOUR

T1 - Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose

T2 - Aktueller Stand und Empfehlungen in Deutschland

AU - Bittner, Stefan

AU - Engel, Sinah

AU - Lange, Christoph

AU - Weber, Martin S.

AU - Haghikia, Aiden

AU - Luessi, Felix

AU - Korn, Thomas

AU - Klotz, Luisa

AU - Bayas, Antonios

AU - Paul, Friedemann

AU - Heesen, Christoph

AU - Stangel, Martin

AU - Wildemann, Brigitte

AU - Bergh, Florian Then

AU - Tackenberg, Björn

AU - Trebst, Corinna

AU - Warnke, Clemens

AU - Linker, Ralf

AU - Kerschensteiner, Martin

AU - Zettl, Uwe

AU - Tumani, Hayrettin

AU - Brück, Wolfgang

AU - Meuth, Sven G.

AU - Kümpfel, Tanja

AU - Hemmer, Bernhard

AU - Wiendl, Heinz

AU - Gold, Ralf

AU - Zipp, Frauke

PY - 2019/12/1

Y1 - 2019/12/1

N2 - After years of low incidence, a large increase of new tuberculosis (TB) cases has been reported in Germany since 2015. New immunotherapies for the treatment of multiple sclerosis (MS) are associated with a reduced immune competence and a potential increased risk for infections. Most neurologists lack specific experiences with TB infections. This article summarizes specific recommendations for the diagnostics and treatment of TB under MS immunotherapies with a focus on the situation in Germany. Due to low case numbers and little experience with the risk of TB under the new immunotherapies, the clinical competence network for MS (KKNMS) consensus recommendations have a low grade of evidence.

AB - After years of low incidence, a large increase of new tuberculosis (TB) cases has been reported in Germany since 2015. New immunotherapies for the treatment of multiple sclerosis (MS) are associated with a reduced immune competence and a potential increased risk for infections. Most neurologists lack specific experiences with TB infections. This article summarizes specific recommendations for the diagnostics and treatment of TB under MS immunotherapies with a focus on the situation in Germany. Due to low case numbers and little experience with the risk of TB under the new immunotherapies, the clinical competence network for MS (KKNMS) consensus recommendations have a low grade of evidence.

KW - Immune monitoring

KW - Multiple sclerosis

KW - Prevention

KW - Treatment

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/85069651235

U2 - 10.1007/s00115-019-0760-0

DO - 10.1007/s00115-019-0760-0

M3 - Übersichtsartikel

C2 - 31297574

AN - SCOPUS:85069651235

SN - 0028-2804

VL - 90

SP - 1245

EP - 1253

JO - Nervenarzt

JF - Nervenarzt

IS - 12

ER -

Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose: Aktueller Stand und Empfehlungen in Deutschland

Abstract

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