Diagnostic performance of susceptibility-weighted magnetic resonance imaging for the detection of calcifcations: A systematic review and meta-analysis

Lisa C. Adams, Keno Bressem, Sarah Maria Böker, Yi Na Yvonne Bender, Dominik Nörenberg, Bernd Hamm, Marcus R. Makowski

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Since its introduction, susceptibility-weighted-magnetic resonance imaging (SW-MRI) has shown the potential to overcome the insensitivity of MRI to calcifcation. Previous studies reporting the diagnostic performance of SW-MRI and magnetic resonance imaging (MRI) for the detection of calcifcations are inconsistent and based on single-institution designs. To our knowledge, this is the frst meta-analysis on SW-MRI, determining the potential of SW-MRI to detect calcifcations. Two independent investigators searched MEDLINE, EMBASE and Web of Science for eligible diagnostic accuracy studies, which were published until March 24, 2017 and investigated the accuracy of SW-MRI to detect calcifcations, using computed tomography (CT) as a reference. The QUADAS-2 tool was used to assess study quality and methods for analysis were based on PRISMA. A bivariate diagnostic random-efects model was applied to obtain pooled sensitivities and specifcities. Out of the 4629 studies retrieved by systematic literature search, 12 clinical studies with 962 patients and a total of 1,032 calcifcations were included. Pooled sensitivity was 86.5% (95%-confdence interval (CI): 73.6-93.7%) for SW-MRI and 36.7% (95%-CI:29.2- 44.8%) for standard MRI. Pooled specifcities of SW-MRI (90.8%; 95%-CI:81.0-95.8%) and standard MRI (94.2; 95%-CI:88.9-96.7%) were comparable. Results of the present meta-analysis suggest, that SWMRI is a reliable method for detecting calcifcations in soft tissues.

Original languageEnglish
Article number15506
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - 1 Dec 2017
Externally publishedYes

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