Diagnostic accuracy and prognostic value of core biopsy in the management of breast cancer: A series of 542 patients

Christiane Richter-Ehrenstein, Sylvia Müller, Aurelia Noske, Achim Schneider

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Purpose. Core biopsy is considered to be a highly accurate method for gaining preoperative diagnosis of breast cancer. The purpose of this study is to compare the results of core biopsy with those of the surgical excision specimen. Experimental design. A total of 567 core biopsies with subsequent surgical excision were performed. Results. In 488 patients, invasive breast cancer was diagnosed in the preoperative biopsy and in 486 patients (99.6%) the surgical specimen showed identical results. In 160 of the 502 patients (32%) with invasive breast cancer, DCIS was found in the surgical specimen but was not diagnosed in the biopsy. Estrogen and progesterone receptor demonstrated a high rate of agreement, Her2/neu analysis showed a complete concordance in 54% of patients. Conclusions. Core biopsies allow diagnosis of invasive breast cancer with high accuracy. Levels of agreement have to be improved for the detection of DCIS and Her2/neu status.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalInternational Journal of Surgical Pathology
Volume17
Issue number4
DOIs
StatePublished - Aug 2009
Externally publishedYes

Keywords

  • Breast cancer
  • Core biopsy
  • DCIS
  • Excision
  • Her2/neu
  • Histological grade

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