Diabetes-related antibodies in euglycemic subjects

Peter Achenbach; Anette G. Ziegler

doi:10.1016/j.beem.2004.11.009

Diabetes-related antibodies in euglycemic subjects

Peter Achenbach, Anette G. Ziegler

City Hospital Munich-Schwabing

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Type 1 diabetes mellitus is preceded by autoimmunity against the insulin-producing islet β cells. Autoantibodies against islet antigens such as insulin, glutamic acid decarboxylase, and the protein tyrosine phosphatase-like molecule IA-2 are found in most patients with type 1 diabetes and are now established markers for the clinical diagnosis and the preclinical phase of this disease. The development of islet autoantibodies and diabetes is influenced by genetic and environmental factors, and the detection and characterization of islet autoantibodies in euglycemic members of affected families identifies some individuals who have a markedly elevated risk for type 1 diabetes. This ability to accurately predict diabetes risk in non-diabetic subjects will prove very useful for targeted recruitment of participants of interventional studies aimed at preventing the progression to type 1 diabetes in subjects at risk.

Original language	English
Pages (from-to)	101-117
Number of pages	17
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.beem.2004.11.009
State	Published - Mar 2005
Externally published	Yes

Keywords

Autoantibody
Diagnosis
Pathogenesis
Prediction
Prevalence
Type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.beem.2004.11.009

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title = "Diabetes-related antibodies in euglycemic subjects",

abstract = "Type 1 diabetes mellitus is preceded by autoimmunity against the insulin-producing islet β cells. Autoantibodies against islet antigens such as insulin, glutamic acid decarboxylase, and the protein tyrosine phosphatase-like molecule IA-2 are found in most patients with type 1 diabetes and are now established markers for the clinical diagnosis and the preclinical phase of this disease. The development of islet autoantibodies and diabetes is influenced by genetic and environmental factors, and the detection and characterization of islet autoantibodies in euglycemic members of affected families identifies some individuals who have a markedly elevated risk for type 1 diabetes. This ability to accurately predict diabetes risk in non-diabetic subjects will prove very useful for targeted recruitment of participants of interventional studies aimed at preventing the progression to type 1 diabetes in subjects at risk.",

keywords = "Autoantibody, Diagnosis, Pathogenesis, Prediction, Prevalence, Type 1 diabetes",

author = "Peter Achenbach and Ziegler, {Anette G.}",

note = "Funding Information: Using sophisticated measurements of islet autoantibodies we are able to predict type 1 diabetes and trace its natural history. We have little idea, however, of the etiologic mechanisms that trigger autoimmunity and promote progression to disease, nor do we have ready access to the autoreactive T cells within the pancreas that are responsible for disease or an ability to quantify and characterize these cells. Advances in these areas are necessary if we are to fully understand the autoimmune pathogenesis of type 1 diabetes. An international initiative sponsored by the National Institute of Health (NIH) has recently commenced an ambitious study (The Environmental Determinants of Diabetes in the Young-TEDDY-study) to address the early pathogenic mechanisms operating in islet autoimmunity ( www.teddystudy.org ). ",

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AU - Ziegler, Anette G.

N1 - Funding Information: Using sophisticated measurements of islet autoantibodies we are able to predict type 1 diabetes and trace its natural history. We have little idea, however, of the etiologic mechanisms that trigger autoimmunity and promote progression to disease, nor do we have ready access to the autoreactive T cells within the pancreas that are responsible for disease or an ability to quantify and characterize these cells. Advances in these areas are necessary if we are to fully understand the autoimmune pathogenesis of type 1 diabetes. An international initiative sponsored by the National Institute of Health (NIH) has recently commenced an ambitious study (The Environmental Determinants of Diabetes in the Young-TEDDY-study) to address the early pathogenic mechanisms operating in islet autoimmunity ( www.teddystudy.org ).

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N2 - Type 1 diabetes mellitus is preceded by autoimmunity against the insulin-producing islet β cells. Autoantibodies against islet antigens such as insulin, glutamic acid decarboxylase, and the protein tyrosine phosphatase-like molecule IA-2 are found in most patients with type 1 diabetes and are now established markers for the clinical diagnosis and the preclinical phase of this disease. The development of islet autoantibodies and diabetes is influenced by genetic and environmental factors, and the detection and characterization of islet autoantibodies in euglycemic members of affected families identifies some individuals who have a markedly elevated risk for type 1 diabetes. This ability to accurately predict diabetes risk in non-diabetic subjects will prove very useful for targeted recruitment of participants of interventional studies aimed at preventing the progression to type 1 diabetes in subjects at risk.

AB - Type 1 diabetes mellitus is preceded by autoimmunity against the insulin-producing islet β cells. Autoantibodies against islet antigens such as insulin, glutamic acid decarboxylase, and the protein tyrosine phosphatase-like molecule IA-2 are found in most patients with type 1 diabetes and are now established markers for the clinical diagnosis and the preclinical phase of this disease. The development of islet autoantibodies and diabetes is influenced by genetic and environmental factors, and the detection and characterization of islet autoantibodies in euglycemic members of affected families identifies some individuals who have a markedly elevated risk for type 1 diabetes. This ability to accurately predict diabetes risk in non-diabetic subjects will prove very useful for targeted recruitment of participants of interventional studies aimed at preventing the progression to type 1 diabetes in subjects at risk.

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KW - Pathogenesis

KW - Prediction

KW - Prevalence

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Diabetes-related antibodies in euglycemic subjects

Abstract

Keywords

UN SDGs

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