TY - JOUR
T1 - Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin
AU - Reichert, Maximilian
AU - Blume, Karin
AU - Kleger, Alexander
AU - Hartmann, Daniel
AU - Von Figura, Guido
N1 - Publisher Copyright:
© 2016 Maximilian Reichert et al.
PY - 2016
Y1 - 2016
N2 - Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial neoplasia (PanIN), and intraductal papillary mucinous neoplasm (IPMN) is needed. Recent studies on murine PDA models have identified a different exocrine origin for PanINs and IPMNs. In both processes, developmental pathways direct the initiation of PDA precursors from their cellular ancestors. In this review, the current understanding of early PDA development is summarized.
AB - Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial neoplasia (PanIN), and intraductal papillary mucinous neoplasm (IPMN) is needed. Recent studies on murine PDA models have identified a different exocrine origin for PanINs and IPMNs. In both processes, developmental pathways direct the initiation of PDA precursors from their cellular ancestors. In this review, the current understanding of early PDA development is summarized.
UR - http://www.scopus.com/inward/record.url?scp=84949266494&partnerID=8YFLogxK
U2 - 10.1155/2016/9298535
DO - 10.1155/2016/9298535
M3 - Review article
AN - SCOPUS:84949266494
SN - 1687-9678
VL - 2016
JO - Stem Cells International
JF - Stem Cells International
M1 - 9298535
ER -
