Development of Tailor‐Made Cytostatics Activable by Acid‐Catalyzed Hydrolysis for Selective Tumor Therapy

Lutz F. Tietze, Matthias Beller, Roland Fischer, Michael Lögers, Eckhard Jähde, Karl‐Heinz ‐H Glüsenkamp, Manfred F. Rajewsky

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The diamidophosphate 1, which is hardly toxic at physiological pH (7.2), undergoes cleavage at pH 6.2 (the pH value found in tumor cells) to glucose, methanol, and a cytotoxic ketone (t½ = 15 h). The survival rate of tumor cells can thereby be decreased in vitro by a factor of 5×104. (Figure Presented.)

Original languageEnglish
Pages (from-to)782-783
Number of pages2
JournalAngewandte Chemie International Edition in English
Volume29
Issue number7
DOIs
StatePublished - Jul 1990
Externally publishedYes

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