TY - GEN
T1 - Development of a multiparametric handheld biosensor for use in mobile applications
AU - Schmidhuber, Michael
AU - Becker, Bernhard
AU - Wiest, Joachim
AU - Wolf, Bernhard
PY - 2009
Y1 - 2009
N2 - Assays entirely based on cells often require large stationary devices for the use in a laboratory environment. As cells are very sensitive the impact of various agents and compounds can be observed. The potential to understand the dynamics of cellular processes justified the development of Lab-on-a-Chip- Systems which allow measurement of the cellular activity in real time. Cells work as signal transducers. The handheld device introduced herein is able to collect the data of the metabolism in the cells micro milieu. Extracellular acidification (pH), oxygen consumption (pO 2) as well as morphology (impedance, for adherent cell lines) can be monitored online. For Point of Care operation the presented Micro-Lab (μLa) uses yeast cells for testing for harmful agents or compounds. This paper describes the technological background of the biosensor system together with its sensor technology. The set-up of cell experiments is described. The concept of an energy-saving microfluidic system is provided as well as data interpretation algorithms and measurement results are presented.
AB - Assays entirely based on cells often require large stationary devices for the use in a laboratory environment. As cells are very sensitive the impact of various agents and compounds can be observed. The potential to understand the dynamics of cellular processes justified the development of Lab-on-a-Chip- Systems which allow measurement of the cellular activity in real time. Cells work as signal transducers. The handheld device introduced herein is able to collect the data of the metabolism in the cells micro milieu. Extracellular acidification (pH), oxygen consumption (pO 2) as well as morphology (impedance, for adherent cell lines) can be monitored online. For Point of Care operation the presented Micro-Lab (μLa) uses yeast cells for testing for harmful agents or compounds. This paper describes the technological background of the biosensor system together with its sensor technology. The set-up of cell experiments is described. The concept of an energy-saving microfluidic system is provided as well as data interpretation algorithms and measurement results are presented.
KW - Cell based system
KW - Live cell analysis
KW - Point-of-care
UR - http://www.scopus.com/inward/record.url?scp=70449640164&partnerID=8YFLogxK
U2 - 10.1109/EURCON.2009.5167610
DO - 10.1109/EURCON.2009.5167610
M3 - Conference contribution
AN - SCOPUS:70449640164
SN - 9781424438617
T3 - IEEE EUROCON 2009, EUROCON 2009
SP - 94
EP - 101
BT - IEEE EUROCON 2009, EUROCON 2009
T2 - IEEE EUROCON 2009, EUROCON 2009
Y2 - 18 May 2009 through 23 May 2009
ER -