Development of a general palladium-catalyzed carbonylative heck reaction of aryl halides

Xiao Feng Wu, Helfried Neumann, Anke Spannenberg, Thomas Schulz, Haijun Jiao, Matthias Beller

Research output: Contribution to journalArticlepeer-review

208 Scopus citations

Abstract

The first general palladium-catalyzed carbonylative vinylation of aryl halides with olefins in the presence of CO has been developed. Applying a catalyst system consisting of [(cinnamyl)PdCl]2 and bulky imidazolyl-phosphine ligand L1 allows for the efficient and selective synthesis of α,β-unsaturated ketones under mild reaction conditions. Starting from easily available aryl halides and olefins, versatile building blocks can be prepared in a straightforward manner. The generality and functional group tolerance of this novel protocol is demonstrated.

Original languageEnglish
Pages (from-to)14596-14602
Number of pages7
JournalJournal of the American Chemical Society
Volume132
Issue number41
DOIs
StatePublished - 20 Oct 2010
Externally publishedYes

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