Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat

Karl Heinz Summer; Helmut Greim

doi:10.1016/0006-291X(80)91393-5

Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat

Karl Heinz Summer, Helmut Greim

Helmholtz Zentrum München German Research Center for Environmental Health

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Biotransformation of chloroprene (2-chloro-1,3-butadiene) in the rat or in isolated rat hepatocytes leads to glutathione conjugates with concomitant depletion of hepatic glutathione and increased excretion rates of urinary thioethers. Conjugate formation depends on microsomal enzyme activities suggesting the involvement of an epoxide intermediate.

Original language	English
Pages (from-to)	566-573
Number of pages	8
Journal	Topics in Catalysis
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(80)91393-5
State	Published - 1980
Externally published	Yes

Keywords

5,5′-dithio-bis(2-nitrobenzoic acid)
DTNB
GSH
GSSG
lactatedehydrogenase
LDH
oxidized glutathione
reduced glutathione

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10.1016/0006-291X(80)91393-5

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title = "Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat",

abstract = "Biotransformation of chloroprene (2-chloro-1,3-butadiene) in the rat or in isolated rat hepatocytes leads to glutathione conjugates with concomitant depletion of hepatic glutathione and increased excretion rates of urinary thioethers. Conjugate formation depends on microsomal enzyme activities suggesting the involvement of an epoxide intermediate.",

keywords = "5,5′-dithio-bis(2-nitrobenzoic acid), DTNB, GSH, GSSG, lactatedehydrogenase, LDH, oxidized glutathione, reduced glutathione",

author = "Summer, {Karl Heinz} and Helmut Greim",

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doi = "10.1016/0006-291X(80)91393-5",

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pages = "566--573",

journal = "Topics in Catalysis",

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T1 - Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat

AU - Summer, Karl Heinz

AU - Greim, Helmut

PY - 1980

Y1 - 1980

N2 - Biotransformation of chloroprene (2-chloro-1,3-butadiene) in the rat or in isolated rat hepatocytes leads to glutathione conjugates with concomitant depletion of hepatic glutathione and increased excretion rates of urinary thioethers. Conjugate formation depends on microsomal enzyme activities suggesting the involvement of an epoxide intermediate.

AB - Biotransformation of chloroprene (2-chloro-1,3-butadiene) in the rat or in isolated rat hepatocytes leads to glutathione conjugates with concomitant depletion of hepatic glutathione and increased excretion rates of urinary thioethers. Conjugate formation depends on microsomal enzyme activities suggesting the involvement of an epoxide intermediate.

KW - 5,5′-dithio-bis(2-nitrobenzoic acid)

KW - DTNB

KW - GSH

KW - GSSG

KW - lactatedehydrogenase

KW - LDH

KW - oxidized glutathione

KW - reduced glutathione

UR - http://www.scopus.com/inward/record.url?scp=0019170151&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(80)91393-5

DO - 10.1016/0006-291X(80)91393-5

M3 - Article

C2 - 7425999

AN - SCOPUS:0019170151

VL - 96

SP - 566

EP - 573

JO - Topics in Catalysis

JF - Topics in Catalysis

IS - 2

ER -

Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat

Abstract

Keywords

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