Determination of individual S-values for 131I using segmented CT data and the EGS4 Monte Carlo code

Ingo Wolf, Maria Zankl, Klemens Scheidhauer, Eugenia Vabuliene, Dieter Regula, Christoph Von Schilling, Markus Schwaiger

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In individual voxel phantoms, which were segmented from whole-body computed tomography (CT) scans, S-values were calculated for 131I using the EGS4 Monte Carlo code and compared to Medical Internal Radiation Dose (MIRD) S-values, which were derived from transport calculations in idealized mathematical phantoms. The individually calculated S-values agree very well with the MIRD values for organs, which are source and target simultaneously, when individual organ-mass corrections are applied to the MIRD values. For different source-target combinations, large deviations up to 184% were found. The contribution of the gamma-absorbed fractions to the total dose, however, is small (∼4%). We conclude, therefore, that individual transport calculations in radionuclide-targeted therapies are not necessary for macroscopic dose estimates. Reliable dosimetry is reduced to the problem of accurate activity determination in vivo.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalCancer Biotherapy and Radiopharmaceuticals
Issue number1
StatePublished - 2005


  • Dosimetry
  • Individual phantoms
  • Medical Internal Radiation Dose (MIRD)
  • Radionuclide therapy


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