Detection of TT Virus DNA in blood donors and patients with hepatitis of unknown etiology

Ye I. Isaeva; S. N. Kuzin; A. N. Stepanov; V. F. Uchalkin; R. S. Ross; M. Roggendorf; S. O. Vyazov; D. K. Lvov

Detection of TT Virus DNA in blood donors and patients with hepatitis of unknown etiology

Ye I. Isaeva, S. N. Kuzin, A. N. Stepanov, V. F. Uchalkin, R. S. Ross, M. Roggendorf, S. O. Vyazov, D. K. Lvov

Institute of Virology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A new human infective agent: TT virus (TTV) has been recently identified. The polymerase chain reaction detected TTV DNA in the sera of 5 (31.3%) out of 16 children with acute hepatitis, 5 (17.2%) out of 29 children and 3 (14.3%) out of 21 adults with liver diseases of unknown etiology, and 18 (13.2%) out of 136 free-of-charge blood donors. These results indicate a high prevalence of TTV infection in Russia and absence of an obvious correlation between this infection and nonA, nonB, nonC hepatitis in examined patients. Phylogenetic analysis of amplified fragments of viral DNA from 3 patients selected at random showed that the isolated strains belong to subtype 1a, most prevalent in the world.

Original language	English
Pages (from-to)	170-171
Number of pages	2
Journal	Voprosy Virusologii
Volume	44
Issue number	4
State	Published - 1999

Keywords

Hepatitis
Polymerase chain reaction
TT virus (TTV)
Virus DNA

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Detection of TT Virus DNA in blood donors and patients with hepatitis of unknown etiology",

abstract = "A new human infective agent: TT virus (TTV) has been recently identified. The polymerase chain reaction detected TTV DNA in the sera of 5 (31.3%) out of 16 children with acute hepatitis, 5 (17.2%) out of 29 children and 3 (14.3%) out of 21 adults with liver diseases of unknown etiology, and 18 (13.2%) out of 136 free-of-charge blood donors. These results indicate a high prevalence of TTV infection in Russia and absence of an obvious correlation between this infection and nonA, nonB, nonC hepatitis in examined patients. Phylogenetic analysis of amplified fragments of viral DNA from 3 patients selected at random showed that the isolated strains belong to subtype 1a, most prevalent in the world.",

keywords = "Hepatitis, Polymerase chain reaction, TT virus (TTV), Virus DNA",

author = "Isaeva, {Ye I.} and Kuzin, {S. N.} and Stepanov, {A. N.} and Uchalkin, {V. F.} and Ross, {R. S.} and M. Roggendorf and Vyazov, {S. O.} and Lvov, {D. K.}",

year = "1999",

language = "English",

volume = "44",

pages = "170--171",

journal = "Voprosy Virusologii",

issn = "0507-4088",

publisher = "Central Research Institute for Epidemiology",

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}

TY - JOUR

T1 - Detection of TT Virus DNA in blood donors and patients with hepatitis of unknown etiology

AU - Isaeva, Ye I.

AU - Kuzin, S. N.

AU - Stepanov, A. N.

AU - Uchalkin, V. F.

AU - Ross, R. S.

AU - Roggendorf, M.

AU - Vyazov, S. O.

AU - Lvov, D. K.

PY - 1999

Y1 - 1999

N2 - A new human infective agent: TT virus (TTV) has been recently identified. The polymerase chain reaction detected TTV DNA in the sera of 5 (31.3%) out of 16 children with acute hepatitis, 5 (17.2%) out of 29 children and 3 (14.3%) out of 21 adults with liver diseases of unknown etiology, and 18 (13.2%) out of 136 free-of-charge blood donors. These results indicate a high prevalence of TTV infection in Russia and absence of an obvious correlation between this infection and nonA, nonB, nonC hepatitis in examined patients. Phylogenetic analysis of amplified fragments of viral DNA from 3 patients selected at random showed that the isolated strains belong to subtype 1a, most prevalent in the world.

AB - A new human infective agent: TT virus (TTV) has been recently identified. The polymerase chain reaction detected TTV DNA in the sera of 5 (31.3%) out of 16 children with acute hepatitis, 5 (17.2%) out of 29 children and 3 (14.3%) out of 21 adults with liver diseases of unknown etiology, and 18 (13.2%) out of 136 free-of-charge blood donors. These results indicate a high prevalence of TTV infection in Russia and absence of an obvious correlation between this infection and nonA, nonB, nonC hepatitis in examined patients. Phylogenetic analysis of amplified fragments of viral DNA from 3 patients selected at random showed that the isolated strains belong to subtype 1a, most prevalent in the world.

KW - Hepatitis

KW - Polymerase chain reaction

KW - TT virus (TTV)

KW - Virus DNA

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M3 - Article

C2 - 10500985

AN - SCOPUS:0033162581

SN - 0507-4088

VL - 44

SP - 170

EP - 171

JO - Voprosy Virusologii

JF - Voprosy Virusologii

IS - 4

ER -

Detection of TT Virus DNA in blood donors and patients with hepatitis of unknown etiology

Abstract

Keywords

UN SDGs

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