Designability and disease

Philip Wong, Dmitrij Frishman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Structural designability is the number of ways it is possible to encode for structure. A protein's designability has been equated with the size of sequence space encoding for the protein's structure, a measure that reflects the structure's robustness to mutation. Current evidence suggests that designability is fundamental to our understanding of the evolvability and distribution of structures in nature and is a significant factor associated with human disease. Here, we describe definitions and principles underlying the concept of designability and discuss its relation to disease.

Original languageEnglish
Title of host publicationFunctional Proteomics
Subtitle of host publicationMethods and Protocols
EditorsJulie D. Thompson, Marius Ueffing, Christine Schaeffer-Reiss
Number of pages14
StatePublished - 2008
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Disease
  • Genome analysis
  • Protein evolution
  • Structure classification


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